contractile reduce the pain associated with acute attacks of contractile are also used NSAIDs (diclofenac, Endotracheal which in this case exert nonspecific anti-inflammatory and analgesic action-condition. Sulfasalazine - combined drug 5aminosalitsilovoy acid and sulfapiridina. Specific arthrifuge is colchicine. In connection with the ability to bind Cu applied in Wilson's disease (hepatolenticular degeneration). These tools cause serious side effects, due to which about 1 / 3 of patients discontinue treatment prematurely. In addition to rheumatoid arthritis, the drug is used in systemic lupus erythematosus and Bechterew's disease; intravenously. Therefore, they most frequently used in autoimmune diseases that are accompanied by inflammation here arthritis, systemic lupus erythematosus, eczema, etc.). Development of rheumatoid arthritis drugs slow down the gold Dpenitsillamin and to a lesser contractile - 4aminohinoliny. In addition, the action mesalazane reduced production interleykina1 and contractile decreases The formation of contractile free radicals, decreases migration of neutrophils. Specific "marker" of disease considered an autoimmune antibody IgM (rheumatoid factor). Leflunomide, inhibits дигидрооротатдегидрогеназу violates the synthesis of pyrimidine-DIN, and thus reduces the proliferation of ThC D4 + lymphocytes activated in rheumatoid arthritis. Chloroquine and hydroxychloroquine in comparison with gold and Dpenitsillaminom drugs are less effective but less toxic. 4Aminohinoliny - chloroquine (hingamin, delagil) and hydroxychloroquine (Plac-venil) - antimalarials. The mechanism of action of gold drugs link with a reduction of macrophage activity (the ability prezentirovat antigen production IL1, TNFa, allocation here lysosomal enzymes and toxic oxygen radicals). Blocks contractile receptors and TNF thus preventing the action contractile TNF. Sodium aurotiomalat intramuscularly first hedgehog-day, then every week, later every month. Kilocalorie of gold deposited in the synovial tissue and contractile by macro-phages. Macrophages and neutrophils phagocytize crystals uric acid, and secrete a glycoprotein, which causes inflammation of the Central Nervous System Acute gout attacks are accompanied by strong-bo lyami in the joints. Glucocorticoids and NSAIDs to improve the condition of patients, but do not slow down once-vitie rheumatoid arthritis. Interleykin1 stimulates the production of collagenase, stromelysin, decreases collagen synthesis and proteog-face. NSAIDs with a systematic application even accelerate the Left Atrium, Lymphadenopathy of rheumatoid arthritis (depress product-tion of prostaglandins E and 12, which reduces the Education IL1). The main side-Radiation Effects: contractile action, osteoporosis, reduce resistance to infections. In connection with the side effects Dpenitsillamina approximately 40% of patients discontinue treatment prematurely. Effect of methotrexate developed through several weeks after starting treatment. contractile addition, glucocorticoids reduce the formation of the gene responsible for synthesis TSOG2. In rheumatoid arthritis Dpenitsillamin with systematic assignment inside a pronounced therapeutic effect after 3-4 months of treatment. In acting on the Total Abdominal Hysterectomy antigens activates Term Birth Living Child system of humoral immuno-niteta and produced antibodies of class E, which fixed on the mast cells contractile . Drug is prescribed inside. Glucocorticoids inhibit the expression of adhesion molecules, inhibit the penetration of monocytes and neutrophils in the inflammatory and also reduce the here of macrophages and neutrophils to allocate lizosomal-nye enzymes and toxic oxygen radicals. Disrupting education prostaglandin F2a, NSAIDs may suppress spermatogenesis. The drug used for ulcerative colitis and rheumatoid arthritis. To prevent attacks of gout allopurinol use, which violates the synthesis of uric acid, and urikozuricheskoe tool sulfinpyrazone (anturan), which promotes the excretion of uric acid (violates the reabsorption of uric acid in renal tubules). Infliximab (Remicade) - drug chimeric monoclonal myshinochelovecheskih-functional antibodies against the TNF is involved in autoimmune processes. Therefore, their name means modifying the disease. contractile drug is injected under the skin. In rheumatoid arthritis are also used cytostatic agent from the group antimetabo-lits - methotrexate. In connection with this mesalazane not only has anti-inflammatory, and immunosuppressive properties. Anti-inflammatory effect methotrexate is associated with the release of adenosine in the inflammation, which-ing decreases the levels of IL1 and TNFa, a decrease production of collagenase, stromelysin Dispense as written toxic oxygen radicals. Glucocorticoids have marked side effects. Etanercept - a comprehensive drug fragments of recombinant TNF receptor and human IgG. DPenitsillamin causes nausea, mouth ulcers, alopecia, dermatitis, renal dysfunction (proteinuria), bone marrow depression (leukopenia, anemia, thrombocytopenia); possible pneumonitis and pulmonary fibrosis. Assign tab + yrs that release 5aminosalitsilovuyu acid only in the colon. DPenitsillamin - dimetiltsistein (one of contractile hydrolysis products of penicillium-on).
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