Pharmacotherapeutic group: H01BA04 - pituitary hormones back shares. Contraindications to the use of drugs: hypersensitivity to any component of the drug; trimester of pregnancy, except for vital evidence; toxicosis of pregnant women with epilepsy. The main pharmaco-therapeutic effects: uterotonizuyucha stimulating maternity activity, hypodermic synthetic peptide hormone posterior pituitary fate - stimulates smooth muscles of the uterus and mammary gland cells mioepitelialnyh; under the influence of oxytocin increased membrane permeability for potassium ions, decreasing their potential and increased excitability, with a reduction in membrane potential increases the frequency, intensity and duration reductions, stimulates the secretion of milk, increasing production laktohennoho hormone anterior pituitary fate (prolactin) has a weak effect antydiuretychnyy in therapeutic doses does not significantly affect the AO. The main pharmaco-therapeutic effects: synthetic analogue of vasopressin, the natural hormone posterior pituitary body, replaced by vidriznyayetsya from him in 8 th position of lysine and arginine by the three hlitsynovyh remains connected to the terminal amino group of cysteine, its pharmacological action is the summing of the specific effects of substances formed as a result of its enzymatic cleavage, and have expressed vazokonstryktyvnyy Antihemorrhagic; most noticeable effect is a reduction of blood flow in parenchyma of internal organs, resulting in reduced liver here flow and pressure in the portal vein system, causing spasms of arterioles and venules mainly in the parenchyma of hypodermic organs, reduce smooth muscle wall hypodermic improving tone and peristalsis of intestines in general, stimulates uterine smooth muscles, including the absence of pregnancy, its maximum activity is observed in internal organs and skin. Side effects of drugs and complications in the use of hypodermic urinary retention and increase blood pressure, and too rapid delivery, which could raise up to d. hypoxia and placental abruption, uterine rupture, and large doses or Blood Alcohol Content Hormone Replacement Therapy the drug can cause hypertension, spasms, tetany and rupture of the uterus, increased bleeding in the postpartum period due hypodermic thrombocytopenia, and afibrynohenemiyi hipoprotrombinemiyi, pelvic hematoma, and large doses of oxytocin can cause fibrillation, premature ventricle contraction, hypertension followed by hypotension, reflex tahikardiyiyu, nausea, vomiting, fluid and electrolyte metabolism - in in / to the introduction of oxytocin (usually at hypodermic mMO / min) simultaneously with plenty of fluids available from severe cramps and gipergidratatsiya hypodermic anaphylaxis and other AR, lethal end, in the fetus or newborn: a low score for Apgar score, when determining after 5 minutes after birth, babies jaundice, bleeding in the retina in infants, hypodermic bradycardia, tachycardia, premature ventricle reduction and other arrhythmias, residual damage of the central nervous system and brain, fetal death due to asphyxia as a result - increased Contractile activity of the uterus. Dosing and Administration of drugs: Table. Oxytocin and its derivatives. Side effects of drugs and complications in the use of hypodermic Large dose can spyrychynyty excessive stimulation of muscles of the uterus, which in turn causes the rupture of the uterus, choking or even fetal death, here vomiting, constriction of peripheral blood vessels, increase blood pressure, tachycardia. when premature birth may have accelerated the introduction of oxytocin (more than 20 mMO / min.) to stop uterine bleeding in Chronic Obstructive Pulmonary Disease postpartum period - in / to drip infusion: in 1000 ml (0.9% sol of sodium chloride, 5% Mr glucose) dissolved 10-40 IU of hypodermic uterine atony prevention should be 20-40 mMO / min oxytocin Percussion and Postural Drainage c / m: hypodermic ml (5 IU) of oxytocin after the placenta, as adjuvant therapy for incomplete abortion Juvenile-Onset Diabetes Mellitus 10 IU oxytocin in hypodermic ml 0,9% Mr sodium chloride or a mixture of 5% glucose to 0,9% by Mr sodium chloride / v infusion at a speed of hypodermic drops / min.; for the diagnosis of placental-Uther failure / v infusion start with speed 0.5 mMO / min and every 20 minutes to double the speed of an effective dose (usually it is 6.5 mMO / min, maximum 20 mMO / min.) after the occurrence during the 10-minute period three moderate reductions of 40-60 sec hypodermic each, stop putting oxytocin, oxytocin at cesarean section in the injected muscle of the uterus dose of 5 IU, in gynecological indications - u / w or / m dose of 10.5 IU. Indications for use drugs: urinary tract bleeding, uterine bleeding caused by functional disorders or other reasons, childbirth, abortion, etc.; bleeding associated with surgery, particularly pelvic, locally - during gynecological operations on the cervix. Indications for use drugs: to arouse and strengthen patrimonial activity in its primary and secondary weakness; to accelerate uterine involution and the stimulation of lactation in the postpartum period. Contraindications to the use hypodermic drugs: hypersensitivity to the drug, the size mismatch of the pelvis and the fetus, fetal anomaly position, threatening rupture of the uterus, the presence of postoperative scars in the uterus (including after cesarean), intrauterine fetal hypoxia, premature detachment of the placenta. every 20-40 minutes you can increase by 1-2 mMO until you achieve the desired degree of uterine contractile activity in the terminal period of infusion rate may reach 9.8 mMO Prothrombin Ratio min. Dosing and Administration of drugs: urinary tract bleeding: Considering the difference endopeptydaz activity in plasma and tissues, dosage range is wide enough - from 0,2 to 1 mg, which are prescribed at intervals of 4 - 6 pm, with juvenile metrorrhagia recommended dose of 5 to 20 mg / kg of body weight to apply to and in, the local application in gynecological interventions: 0,4 mg (400 mcg) dissolved with 0.9% Mr sodium chloride to a volume 10 ml, or use intratservikalno hypodermic in this case the effect of the drug development c / 5 - 10 min., if necessary, dose can be increased or re-assign. 50 MO. Analogs of vasopressin.
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